Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether

Makoto Sasaki, Chihiro Tsukano, Kazuo Tachibana

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether, has been achieved based on the B-alkyl Suzuki-Miyaura coupling-based strategy and radical cyclization for the construction of the tetrahydrofuran ring A.

Original languageEnglish
Pages (from-to)4351-4354
Number of pages4
JournalTetrahedron Letters
Volume44
Issue number23
DOIs
Publication statusPublished - 2003 Jun 2

Keywords

  • B-alkyl Suzuki-Miyaura coupling
  • Gymnocin-A
  • Polycyclic ethers
  • Radical cyclization

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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