Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether

Makoto Sasaki; Chihiro Tsukano; Kazuo Tachibana

doi:10.1016/S0040-4039(03)00949-3

Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether

Makoto Sasaki, Chihiro Tsukano, Kazuo Tachibana

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether, has been achieved based on the B-alkyl Suzuki-Miyaura coupling-based strategy and radical cyclization for the construction of the tetrahydrofuran ring A.

Original language	English
Pages (from-to)	4351-4354
Number of pages	4
Journal	Tetrahedron Letters
Volume	44
Issue number	23
DOIs	https://doi.org/10.1016/S0040-4039(03)00949-3
Publication status	Published - 2003 Jun 2

Keywords

B-alkyl Suzuki-Miyaura coupling
Gymnocin-A
Polycyclic ethers
Radical cyclization

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0040-4039(03)00949-3

Cite this

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title = "Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether",

abstract = "Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether, has been achieved based on the B-alkyl Suzuki-Miyaura coupling-based strategy and radical cyclization for the construction of the tetrahydrofuran ring A.",

keywords = "B-alkyl Suzuki-Miyaura coupling, Gymnocin-A, Polycyclic ethers, Radical cyclization",

author = "Makoto Sasaki and Chihiro Tsukano and Kazuo Tachibana",

note = "Funding Information: We thank Professor M. Satake of Tohoku University for valuable discussions. This work was financially supported in part by a grant from Suntory Institute for Bioorganic Research (SUNBOR).",

year = "2003",

month = jun,

day = "2",

doi = "10.1016/S0040-4039(03)00949-3",

language = "English",

volume = "44",

pages = "4351--4354",

journal = "Tetrahedron Letters",

issn = "0040-4039",

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number = "23",

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TY - JOUR

T1 - Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether

AU - Sasaki, Makoto

AU - Tsukano, Chihiro

AU - Tachibana, Kazuo

N1 - Funding Information: We thank Professor M. Satake of Tohoku University for valuable discussions. This work was financially supported in part by a grant from Suntory Institute for Bioorganic Research (SUNBOR).

PY - 2003/6/2

Y1 - 2003/6/2

N2 - Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether, has been achieved based on the B-alkyl Suzuki-Miyaura coupling-based strategy and radical cyclization for the construction of the tetrahydrofuran ring A.

AB - Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether, has been achieved based on the B-alkyl Suzuki-Miyaura coupling-based strategy and radical cyclization for the construction of the tetrahydrofuran ring A.

KW - B-alkyl Suzuki-Miyaura coupling

KW - Gymnocin-A

KW - Polycyclic ethers

KW - Radical cyclization

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U2 - 10.1016/S0040-4039(03)00949-3

DO - 10.1016/S0040-4039(03)00949-3

M3 - Article

AN - SCOPUS:0038369821

SN - 0040-4039

VL - 44

SP - 4351

EP - 4354

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 23

ER -

Synthetic entry to the ABCD ring fragment of gymnocin-A, a cytotoxic marine polyether

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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