Synthesis of triazole-linked analogues of RNA (TLRNA)

Tomoko Fujino; Kenta Endo; Naomi Yamazaki; Hiroyuki Isobe

doi:10.1246/cl.2012.403

Synthesis of triazole-linked analogues of RNA (TLRNA)

Tomoko Fujino, Kenta Endo, Naomi Yamazaki, Hiroyuki Isobe

SCI - Chemistry

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

A triazole-linked analogue of RNA (TLRNA) has been developed. Monomeric ribonucleoside analogues bearing natural nucleobases were prepared from D-xylose to afford the elongating units in gram quantities. The puckering of the monomeric analogues was similar to that of natural ribonucleosides and preferred the North-type conformation. An efficient elongation reaction via the copper-catalyzed Huisgen cycloaddition on a solid support was used for the synthesis of trinucleotides.

Original language	English
Pages (from-to)	403-405
Number of pages	3
Journal	Chemistry Letters
Volume	41
Issue number	4
DOIs	https://doi.org/10.1246/cl.2012.403
Publication status	Published - 2012 Apr 24

ASJC Scopus subject areas

Chemistry(all)

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