Synthesis of triazole-linked analogues of RNA (TLRNA)

Tomoko Fujino, Kenta Endo, Naomi Yamazaki, Hiroyuki Isobe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A triazole-linked analogue of RNA (TLRNA) has been developed. Monomeric ribonucleoside analogues bearing natural nucleobases were prepared from D-xylose to afford the elongating units in gram quantities. The puckering of the monomeric analogues was similar to that of natural ribonucleosides and preferred the North-type conformation. An efficient elongation reaction via the copper-catalyzed Huisgen cycloaddition on a solid support was used for the synthesis of trinucleotides.

Original languageEnglish
Pages (from-to)403-405
Number of pages3
JournalChemistry Letters
Volume41
Issue number4
DOIs
Publication statusPublished - 2012 Apr 24

ASJC Scopus subject areas

  • Chemistry(all)

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