Abstract
A triazole-linked analogue of RNA (TLRNA) has been developed. Monomeric ribonucleoside analogues bearing natural nucleobases were prepared from D-xylose to afford the elongating units in gram quantities. The puckering of the monomeric analogues was similar to that of natural ribonucleosides and preferred the North-type conformation. An efficient elongation reaction via the copper-catalyzed Huisgen cycloaddition on a solid support was used for the synthesis of trinucleotides.
Original language | English |
---|---|
Pages (from-to) | 403-405 |
Number of pages | 3 |
Journal | Chemistry Letters |
Volume | 41 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2012 |
ASJC Scopus subject areas
- Chemistry(all)