Abstract
Previously, we established a new strategy of synchronous cross linking reaction activated by hybridization to target genes. In this strategy, the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, is generated from its stable precursors by a hybridization-promoted activation process with selectivity to cytosine. In this paper, we wish to report the synthesis of the peptide nucleic acids (PNAs) incorporating 2-amino-6-vinylpurine derivatives and the evaluation of their reactivity to target DNA.
Original language | English |
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Pages (from-to) | 391-392 |
Number of pages | 2 |
Journal | Nucleic acids symposium series (2004) |
Issue number | 52 |
Publication status | Published - 2008 Dec 1 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)