Synthesis of the peptide nucleic acid (PNA) incorporating 2-amino-6-vinylpurine derivative and evaluation of the reactivity.

Shuhei Imoto, Azusa Shimotazawa, Tomoya Hirohama, Makoto Goto, Fumi Nagatsugi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Previously, we established a new strategy of synchronous cross linking reaction activated by hybridization to target genes. In this strategy, the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, is generated from its stable precursors by a hybridization-promoted activation process with selectivity to cytosine. In this paper, we wish to report the synthesis of the peptide nucleic acids (PNAs) incorporating 2-amino-6-vinylpurine derivatives and the evaluation of their reactivity to target DNA.

Original languageEnglish
Pages (from-to)391-392
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - 2008 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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