Abstract
Previously, we established a new strategy of synchronous cross linking reaction activated by hybridization to target genes. In this strategy, the highly reactive cross-linking agent, 2-amino-6-vinylpurine nucleoside analog, is generated from its stable precursors by a hybridization-promoted activation process with selectivity to cytosine. In this paper, we wish to report the synthesis of the peptide nucleic acids (PNAs) incorporating 2-amino-6-vinylpurine derivatives and the evaluation of their reactivity to target DNA.
| Original language | English |
|---|---|
| Pages (from-to) | 391-392 |
| Number of pages | 2 |
| Journal | Nucleic acids symposium series (2004) |
| Issue number | 52 |
| Publication status | Published - 2008 Dec 1 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
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Imoto, S., Shimotazawa, A., Hirohama, T., Goto, M., & Nagatsugi, F. (2008). Synthesis of the peptide nucleic acid (PNA) incorporating 2-amino-6-vinylpurine derivative and evaluation of the reactivity. Nucleic acids symposium series (2004), (52), 391-392.