Synthesis of the NO ring model of gymnocin-B

Chihiro Tsukano, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

A synthetic route to the NO ring model of gymnocin-B, a cytotoxic marine polycyclic ether with the largest contiguous rings, has been achieved. The synthesis features construction of the seven-membered O ring with 1,3-dimethyl substituents flanking the ether oxygen by ring-closing metathesis.

Original languageEnglish
Pages (from-to)4617-4619
Number of pages3
JournalTetrahedron Letters
Volume46
Issue number27
DOIs
Publication statusPublished - 2005 Jul 4

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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