Synthesis of the L-acid (C1-C18) fragment of pamamycin-593 and De-N-methylpamamycin-579

Ayako Miura, Shin Ya Takigawa, Yukito Furuya, Yusuke Yokoo, Shigefumi Kuwahara, Hiromasa Kiyota

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    The L-acid (C1-C18) fragment of pamamycin-593 and de-N-methylpamamycin-579, strong aerial mycelium-inducers of Streptomyces alboniger, was synthesized using a cis-selective iodoetherification and a nucleophilic addition of a cerium acetylide to an aldehyde as the key steps.

    Original languageEnglish
    Pages (from-to)4955-4962
    Number of pages8
    JournalEuropean Journal of Organic Chemistry
    Issue number29
    DOIs
    Publication statusPublished - 2008 Oct 1

    Keywords

    • Antibiotics
    • Cerium acetylide
    • Iodoetherification
    • Pamamycins
    • Synthesis design

    ASJC Scopus subject areas

    • Physical and Theoretical Chemistry
    • Organic Chemistry

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