Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

Makoto Sasaki; Naoki Takeda; Haruhiko Fuwa; Ryuichi Watanabe; Masayuki Satake; Yasukatsu Oshima

doi:10.1016/j.tetlet.2006.06.032

Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture

Makoto Sasaki, Naoki Takeda, Haruhiko Fuwa, Ryuichi Watanabe, Masayuki Satake, Yasukatsu Oshima

LIF - Molecular and Chemical Life Science

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

Synthesis of the JK/LM-ring model of prymnesins, polycyclic ether toxins isolated from the red tide phytoflagellate, Prymnesium parvum, is described. Comparison of the ¹H and ¹³C NMR data of the synthetic model with those reported for prymnesins confirmed the reported configurational assignment of the K/L-ring juncture.

Original language	English
Pages (from-to)	5687-5691
Number of pages	5
Journal	Tetrahedron Letters
Volume	47
Issue number	32
DOIs	https://doi.org/10.1016/j.tetlet.2006.06.032
Publication status	Published - 2006 Aug 7

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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Sasaki, M., Takeda, N., Fuwa, H., Watanabe, R., Satake, M., & Oshima, Y. (2006). Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture. Tetrahedron Letters, 47(32), 5687-5691. https://doi.org/10.1016/j.tetlet.2006.06.032

Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum : confirmation of the relative configuration of the K/L-ring juncture. / Sasaki, Makoto; Takeda, Naoki; Fuwa, Haruhiko; Watanabe, Ryuichi; Satake, Masayuki; Oshima, Yasukatsu.

In: Tetrahedron Letters, Vol. 47, No. 32, 07.08.2006, p. 5687-5691.

Research output: Contribution to journal › Article

Sasaki, M, Takeda, N, Fuwa, H, Watanabe, R, Satake, M & Oshima, Y 2006, 'Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture', Tetrahedron Letters, vol. 47, no. 32, pp. 5687-5691. https://doi.org/10.1016/j.tetlet.2006.06.032

Sasaki M, Takeda N, Fuwa H, Watanabe R, Satake M, Oshima Y. Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum: confirmation of the relative configuration of the K/L-ring juncture. Tetrahedron Letters. 2006 Aug 7;47(32):5687-5691. https://doi.org/10.1016/j.tetlet.2006.06.032

Sasaki, Makoto ; Takeda, Naoki ; Fuwa, Haruhiko ; Watanabe, Ryuichi ; Satake, Masayuki ; Oshima, Yasukatsu. / Synthesis of the JK/LM-ring model of prymnesins, potent hemolytic and ichthyotoxic polycyclic ethers isolated from the red tide alga Prymnesium parvum : confirmation of the relative configuration of the K/L-ring juncture. In: Tetrahedron Letters. 2006 ; Vol. 47, No. 32. pp. 5687-5691.

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