Abstract
The enantioselective synthesis of the 2-deoxy-α-l-fucosyl lactol moiety of halichoblelide, a potent cytotoxin isolated from an actinomycete of marine origin, was achieved using a diastereoselective addition of a dithianyl anion to a chiral aldehyde intermediate and a stereoselective glycosidation of a hydroxy lactone intermediate derived from the addition product with a protected l-fucal as the key steps.
Original language | English |
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Pages (from-to) | 11733-11737 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 63 |
Issue number | 47 |
DOIs | |
Publication status | Published - 2007 Nov 19 |
Keywords
- Cytotoxic
- Enantioselective synthesis
- Glycosidation
- Halichoblelide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry