Synthesis of the FGH ring fragment of ciguatoxin

M. Sasaki; T. Noguchi; K. Tachibana

doi:10.1016/S0040-4039(98)02606-9

Synthesis of the FGH ring fragment of ciguatoxin

M. Sasaki, T. Noguchi, K. Tachibana

Research output: Contribution to journal › Article › peer-review

84 Citations (Scopus)

Abstract

Stereoselective synthesis of the FGH ring fragment of ciguatoxin is described. The key steps in the present synthesis are an intramolecular radical cyclization to construct oxepane ring G and ring-closing metathesis reaction to construct hexahydrooxonin ring F.

Original language	English
Pages (from-to)	1337-1340
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	7
DOIs	https://doi.org/10.1016/S0040-4039(98)02606-9
Publication status	Published - 1999 Feb 12
Externally published	Yes

Keywords

Metathesis
Oxepanes
Polyethers
Radicals and radical reactions

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)02606-9

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title = "Synthesis of the FGH ring fragment of ciguatoxin",

abstract = "Stereoselective synthesis of the FGH ring fragment of ciguatoxin is described. The key steps in the present synthesis are an intramolecular radical cyclization to construct oxepane ring G and ring-closing metathesis reaction to construct hexahydrooxonin ring F.",

keywords = "Metathesis, Oxepanes, Polyethers, Radicals and radical reactions",

author = "M. Sasaki and T. Noguchi and K. Tachibana",

note = "Funding Information: Acknowledgment:T his work was financiallys upportedb y the Grant-in-Aid for Scientific Researcho n Priority Area No. 08245103fr om the Ministry of Education,S cience,S ports and Culture,o f JapaneseG overnment.",

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doi = "10.1016/S0040-4039(98)02606-9",

language = "English",

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T1 - Synthesis of the FGH ring fragment of ciguatoxin

AU - Sasaki, M.

AU - Noguchi, T.

AU - Tachibana, K.

N1 - Funding Information: Acknowledgment:T his work was financiallys upportedb y the Grant-in-Aid for Scientific Researcho n Priority Area No. 08245103fr om the Ministry of Education,S cience,S ports and Culture,o f JapaneseG overnment.

PY - 1999/2/12

Y1 - 1999/2/12

N2 - Stereoselective synthesis of the FGH ring fragment of ciguatoxin is described. The key steps in the present synthesis are an intramolecular radical cyclization to construct oxepane ring G and ring-closing metathesis reaction to construct hexahydrooxonin ring F.

AB - Stereoselective synthesis of the FGH ring fragment of ciguatoxin is described. The key steps in the present synthesis are an intramolecular radical cyclization to construct oxepane ring G and ring-closing metathesis reaction to construct hexahydrooxonin ring F.

KW - Metathesis

KW - Oxepanes

KW - Polyethers

KW - Radicals and radical reactions

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U2 - 10.1016/S0040-4039(98)02606-9

DO - 10.1016/S0040-4039(98)02606-9

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EP - 1340

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 7

ER -

Synthesis of the FGH ring fragment of ciguatoxin

Abstract

Keywords

ASJC Scopus subject areas

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