Synthesis of the FGH ring fragment of ciguatoxin

M. Sasaki, T. Noguchi, K. Tachibana

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)


Stereoselective synthesis of the FGH ring fragment of ciguatoxin is described. The key steps in the present synthesis are an intramolecular radical cyclization to construct oxepane ring G and ring-closing metathesis reaction to construct hexahydrooxonin ring F.

Original languageEnglish
Pages (from-to)1337-1340
Number of pages4
JournalTetrahedron Letters
Issue number7
Publication statusPublished - 1999 Feb 12
Externally publishedYes


  • Metathesis
  • Oxepanes
  • Polyethers
  • Radicals and radical reactions

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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