Synthesis of the bicyclic [7.3.0] enediyne system of the maduropeptin chromophore: Remarkable atropisomerism of ansamacrolactam and isomerization of the C4-C13 double bond

Nobuki Kato, Satoshi Shimamura, Yoko Kikai, Masahiro Hirama

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A nine-membered diyne system of the maduropeptin chromophore was constructed for the first time using Nozaki-Hiyama-Kishi reaction. Unexpected atropisomerism of deoxyansamacrolactam and cis/trans isomerization of the exo-double bond of the chromophore were observed.

Original languageEnglish
Pages (from-to)2107-2110
Number of pages4
JournalSynlett
Issue number12
DOIs
Publication statusPublished - 2004 Oct 1

Keywords

  • Atropisomerism
  • Chromophore
  • Enediyne
  • Macrolactam
  • Maduropeptin

ASJC Scopus subject areas

  • Organic Chemistry

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