Abstract
The formation of the B ring of the ABC ring system of paclitaxel was accomplished by intramolecular alkylation of the protected cyanohydrin ether in the presence of the 7-alkoxy group on the C ring. A significant effect of the protective groups at the 1,2-positions was observed in this alkylation. Acyclic protection provided the desired compound 3c and 3d in moderate yields, whereas cyclic protection led to 3a in low yield.
Original language | English |
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Pages (from-to) | 97-99 |
Number of pages | 3 |
Journal | Synlett |
Issue number | 1 |
DOIs | |
Publication status | Published - 2002 Jan 1 |
Externally published | Yes |
Keywords
- Cyanohydrins
- Intramolecular alkylations
- Paclitaxel
- Terpenoids
ASJC Scopus subject areas
- Organic Chemistry