Abstract
The first synthesis of the racemate of terpendole E, a speci fic inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.
| Original language | English |
|---|---|
| Pages (from-to) | 11-15 |
| Number of pages | 5 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 79 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 |
Keywords
- Antimitotic
- Indole diterpene
- Kinesin spindle protein
- Terpendole
- Total synthesis
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
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Cite this
Teranishi, T., Murokawa, T., Enomoto, M., & Kuwahara, S. (2015). Synthesis of (±)-terpendole e. Bioscience, Biotechnology and Biochemistry, 79(1), 11-15. https://doi.org/10.1080/09168451.2014.955455