Synthesis of (±)-terpendole e

Takaaki Teranishi, Tetsuro Murokawa, Masaru Enomoto, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    The first synthesis of the racemate of terpendole E, a speci fic inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.

    Original languageEnglish
    Pages (from-to)11-15
    Number of pages5
    JournalBioscience, Biotechnology and Biochemistry
    Volume79
    Issue number1
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Antimitotic
    • Indole diterpene
    • Kinesin spindle protein
    • Terpendole
    • Total synthesis

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

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