Synthesis of (±)-terpendole e

Takaaki Teranishi, Tetsuro Murokawa, Masaru Enomoto, Shigefumi Kuwahara

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The first synthesis of the racemate of terpendole E, a speci fic inhibitor of the mitotic kinesin Eg5, has been achieved from a known tricyclic dihydroxy ketone by a 13-step sequence that involves diastereoselective installation of its C3 quaternary stereocenter via a cyclopropyl ketone intermediate and Pd-mediated two-step construction of the indole ring moiety as the key transformations.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number1
DOIs
Publication statusPublished - 2015

Keywords

  • Antimitotic
  • Indole diterpene
  • Kinesin spindle protein
  • Terpendole
  • Total synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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