Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging

Xiaolei Wang, Miho Emoto, Atsushi Sugimoto, Yusuke Miyake, Kaori Itto, Mitsuo Amasaka, Shu Xu, Hiroshi Hirata, Hirotada Fujii, Hirokazu Arimoto

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


A scalable synthetic route for 15N-labeled 4-oxo-2,2,6,6- tetraethylpiperidine nitroxide (15N-TEEPONE) is described. This 15N-labeled nitroxide is suitable for electron paramagnetic resonance imaging of brain, and its higher sensitivity compared with that of its 14N-counterpart is an important advantage of the labeled derivative.

Original languageEnglish
Pages (from-to)2146-2149
Number of pages4
JournalTetrahedron Letters
Issue number13
Publication statusPublished - 2014 Mar 26
Externally publishedYes


  • EPR imaging
  • Nitroxide radical
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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