Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging

Xiaolei Wang, Miho Emoto, Atsushi Sugimoto, Yusuke Miyake, Kaori Itto, Mitsuo Amasaka, Shu Xu, Hiroshi Hirata, Hirotada Fujii, Hirokazu Arimoto

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    A scalable synthetic route for 15N-labeled 4-oxo-2,2,6,6- tetraethylpiperidine nitroxide (15N-TEEPONE) is described. This 15N-labeled nitroxide is suitable for electron paramagnetic resonance imaging of brain, and its higher sensitivity compared with that of its 14N-counterpart is an important advantage of the labeled derivative.

    Original languageEnglish
    Pages (from-to)2146-2149
    Number of pages4
    JournalTetrahedron Letters
    Volume55
    Issue number13
    DOIs
    Publication statusPublished - 2014 Mar 26

    Keywords

    • EPR imaging
    • Nitroxide radical
    • Synthesis

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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  • Cite this

    Wang, X., Emoto, M., Sugimoto, A., Miyake, Y., Itto, K., Amasaka, M., Xu, S., Hirata, H., Fujii, H., & Arimoto, H. (2014). Synthesis of 15N-labeled 4-oxo-2,2,6,6-tetraethylpiperidine nitroxide for EPR brain imaging. Tetrahedron Letters, 55(13), 2146-2149. https://doi.org/10.1016/j.tetlet.2014.02.063