Abstract
The synthesis of strophasterols C, E, and F has been accomplished from a 14,15-secoergostane derivative via a 1,3-dipolar cycloaddition of a nitrile oxide intermediate to simultaneously install an isolated cyclopentane ring and a C23 oxygen functionality in a diastereoselective manner and a regio- and diastereoselective selenohydroxylation of an olefinic intermediate under thermodynamic conditions. This synthesis also enabled the stereochemical confirmation of strophasterol C.
| Original language | English |
|---|---|
| Pages (from-to) | 1311-1315 |
| Number of pages | 5 |
| Journal | Organic letters |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2020 Feb 21 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry