TY - GEN
T1 - Synthesis of size and shape controlled silver nanoparticles coated by a thin layer of gold and their use as ultrasensitive biomolecular probes
AU - Mott, Derrick
AU - Thuy, Nguyen T.B.
AU - Aoki, Yoshiya
AU - Maenosono, Shinya
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Silver nanoparticles coated by a layer of gold (Ag@Au) have received much attention because of their potential application as ultra sensitive probes for the detection of biologically important molecules such as DNA, proteins, amino acids and many others. However, the ability to control the size, shape, and monodispersity of the Ag@Au structure has met with limited success. In our own research we have addressed this challenge by creating an aqueous wet chemical synthesis technique towards size and shape controllable Ag@Au nanoparticles. These materials are highly interesting because of the tunable silver core size, and the tunable gold shell thickness, opening many avenues to the modification of the particle properties in terms of biomolecular sensing. The resulting nanoparticle probes were functionalized with two complementary stranded DNA oligonucleotides. When combined, the complementary strands hybridized, causing the Ag@Au nanoparticles to assemble into large nano-structures. The presence of the oligonucleotide was confirmed through a series of techniques including UV-Vis and RAMAN spectroscopy, as well as HR-TEM, XPS, DLS, and many others. The results reflect the role that the nanoparticle physical properties play in the detection of the bio-molecules, as well as elucidate the characteristics of the bio-molecule/nanoparficle interaction.
AB - Silver nanoparticles coated by a layer of gold (Ag@Au) have received much attention because of their potential application as ultra sensitive probes for the detection of biologically important molecules such as DNA, proteins, amino acids and many others. However, the ability to control the size, shape, and monodispersity of the Ag@Au structure has met with limited success. In our own research we have addressed this challenge by creating an aqueous wet chemical synthesis technique towards size and shape controllable Ag@Au nanoparticles. These materials are highly interesting because of the tunable silver core size, and the tunable gold shell thickness, opening many avenues to the modification of the particle properties in terms of biomolecular sensing. The resulting nanoparticle probes were functionalized with two complementary stranded DNA oligonucleotides. When combined, the complementary strands hybridized, causing the Ag@Au nanoparticles to assemble into large nano-structures. The presence of the oligonucleotide was confirmed through a series of techniques including UV-Vis and RAMAN spectroscopy, as well as HR-TEM, XPS, DLS, and many others. The results reflect the role that the nanoparticle physical properties play in the detection of the bio-molecules, as well as elucidate the characteristics of the bio-molecule/nanoparficle interaction.
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U2 - 10.1557/proc-1253-k09-04
DO - 10.1557/proc-1253-k09-04
M3 - Conference contribution
AN - SCOPUS:79951643682
SN - 9781605112305
T3 - Materials Research Society Symposium Proceedings
SP - 61
EP - 66
BT - Functional Materials and Nanostructures for Chemical and Biochemical Sensing
PB - Materials Research Society
ER -