Abstract
(Equation presented) A mild intermolecular copper-mediated amination of aryl iodides has been developed. The reaction takes place at room temperature or heating at 90°C and tolerates halogens attached to the aromatic ring. Its synthetic applications include a synthetic protocol for unsymmetrical N,N′-dialkylated phenylenediamines and both a stepwise and a general synthetic method for N-aryl secondary amines via Ns-anilides (readily obtained by reaction of the Ns-amide).
Original language | English |
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Pages (from-to) | 4987-4990 |
Number of pages | 4 |
Journal | Organic letters |
Volume | 5 |
Issue number | 26 |
DOIs | |
Publication status | Published - 2003 Dec 25 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry