Synthesis of pyrroloazepines. Facile synthesis of 2-substituted pyrrole derivatives by the phosgene method

Hidetsura Cho, Shinsuke Matsuki, Akira Mizuno, Hirokazu Annoura, Toshio Tatsuoka

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

A highly convenient method for the synthesis of 2-substituted pyrrole derivatives 7a-c from pyrrole using phosgene was developed. Successively, 7-methyl-6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 1a and 6,7-dihydro-1H,5H-pyrrolo[2,3-c]azepine-4,8-dione 1b (aldisin) were synthesized by phosphorus pentoxide/methanesulfonate and polyphosphoric acid cyclization.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalJournal of Heterocyclic Chemistry
Volume34
Issue number1
DOIs
Publication statusPublished - 1997 Jan 1

ASJC Scopus subject areas

  • Organic Chemistry

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