Synthesis of polysubstituted naphthalenes by iron-catalyzed [2+2+2] annulation of grignard reagents with alkynes

Laurean Ilies, Arimasa Matsumoto, Motoaki Kobayashi, Naohiko Yoshikai, Eiichi Nakamura

Research output: Contribution to journalArticlepeer-review

Abstract

Iron catalyzes the oxidative [2+2+2] annulation of an arylmagnesium compound with two molecules of an internal alkyne via C-H bond activation at 0 °C to produce polysubstituted naphthalene.

Original languageEnglish
Article numberST-2012-U0548-L
Pages (from-to)2381-2384
Number of pages4
JournalSynlett
Volume23
Issue number16
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Alkynes
  • Annulation
  • C-H bond activation
  • Iron
  • Naphthalene

ASJC Scopus subject areas

  • Organic Chemistry

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