Synthesis of pinnaic acid; asymmetric construction of spirocyclic core

Hirokazu Arimoto, Shigehiro Asano, Daisuke Uemura

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

An asymmetric synthesis of the spirocyclic core of pinnaic acid, a cPLA2 inhibitor, is described. A key transformation in the sequence involves an asymmetric Michael-initiated ring closure.

Original languageEnglish
Pages (from-to)3583-3586
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number18
DOIs
Publication statusPublished - 1999 Apr 30
Externally publishedYes

Keywords

  • Alkaloids
  • Asymmetric synthesis
  • Marine metabolites
  • Spiro compounds

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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