Synthesis of photoaffinity probe based on the leaf-opening factor from genus Albizzia

Masahiro Okada, Akira Matsubara, Minoru Ueda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The circadian rhythmic leaf-movements in legumes, called nyctinasty, are regulated by a pair of leaf-closing and -opening factors. Recent fluorescence studies revealed that cis-p-coumaroylagmatine (1), the leaf-opening factor from genus Albizzia, specifically bound to motor cells in a joint of leaf and stem. In order to identify the receptor protein, which is expected to be involved in the plasma membrane of the cell, we designed and synthesized a photoaffinity probe (2), containing a photoreactive azide group on the aromatic ring and FLAG segment as a peptide antigen for immunoprecipitation.

Original languageEnglish
Pages (from-to)3794-3796
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number23
DOIs
Publication statusPublished - 2008 Jun 2

Keywords

  • Albizzia saman
  • Leaf-opening factor
  • Nyctinasty
  • Photoaffinity probe

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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