Synthesis of peptide ribonucleic acid (PRNA)-DNA chimera and interaction with DNA and RNA.

Takehiko Wada, Yoshiki Maeda, Nobuya Sawa, Hirofumi Sato, Hyongi Chon, Shigenori Kanaya, Yoshihisa Inoue

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Recently, we have demonstrated that effective control of the recognition behavior of peptide ribonucleic acid (PRNA) with complementary DNA is possible through the anti-to-synorientational change of pyrimidine nucleobase induced by borate ester formation. In this study, DNA-PRNA chimera was prepared by the solidphase synthesis. In the DNA-PRNA chimeras, both PRNA and DNA domains work as recognition sites for the complementary DNA/RNAs to form stable complex, while DNA-RNA hybrids formed in the DNA domains of DNA-PRNA chimera should be substrates to the hydrolysis by RNase H and PRNA moieties work as recognition control/switching devices and as inhibitor for the hydrolysis by exonucleases. Interaction of the DNA-PRNA chimera with DNA and RNA has been discussed.

Original languageEnglish
Pages (from-to)21-22
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number51
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Medicine(all)

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