Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.

Takehiko Wada, Yusuke Hashimoto, Hirofumi Sato, Yoshihisa Inoue

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.

Original languageEnglish
Pages (from-to)27-28
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number48
Publication statusPublished - 2004 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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