Synthesis of peptide nucleic acids containing a crosslinking agent and evaluation of their reactivities

Takuya Akisawa, Yuki Ishizawa, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Peptide nucleic acids (PNAs) are structural mimics of nucleic acids that form stable hybrids with DNA and RNA. In addition, PNAs can invade double-stranded DNA. Due to these characteristics, PNAs are widely used as biochemical tools, for example, in antisense/antigene therapy. Interstrand crosslink formation in nucleic acids is one of the strategies for preparing a stable duplex by covalent bond formation. In this study, we have synthesized PNAs incorporating 4-amino-6-oxo-2-vinylpyrimidine (AOVP) as a crosslinking agent and evaluated their reactivities for targeting DNA and RNA.

Original languageEnglish
Pages (from-to)4708-4719
Number of pages12
JournalMolecules
Volume20
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

Keywords

  • Antisense
  • Crosslink
  • Invasion
  • Peptide nucleic acid (PNA)

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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