TY - JOUR
T1 - Synthesis of optically active, unnatural α-substituted glutamic acid derivatives by a chiral calcium-catalyzed 1,4-addition reaction
AU - Tsubogo, Tetsu
AU - Kano, Yuichiro
AU - Ikemoto, Koki
AU - Yamashita, Yasuhiro
AU - Kobayashi, Sh
PY - 2010/5/17
Y1 - 2010/5/17
N2 - The first catalytic asymmetric 1,4-addition reactions of azlactones with acrylic esters have been developed. A chiral coordinative calcium catalyst was found to be effective for these reactions, and the desired 1,4-adducts were obtained in good yields and enantioselectivities. The product was converted to the corresponding α-alkylated glutamic acid by acid hydrolysis.
AB - The first catalytic asymmetric 1,4-addition reactions of azlactones with acrylic esters have been developed. A chiral coordinative calcium catalyst was found to be effective for these reactions, and the desired 1,4-adducts were obtained in good yields and enantioselectivities. The product was converted to the corresponding α-alkylated glutamic acid by acid hydrolysis.
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U2 - 10.1016/j.tetasy.2010.03.004
DO - 10.1016/j.tetasy.2010.03.004
M3 - Article
AN - SCOPUS:77956709303
VL - 21
SP - 1221
EP - 1225
JO - Tetrahedron Asymmetry
JF - Tetrahedron Asymmetry
SN - 0957-4166
IS - 9-10
ER -