Synthesis of open-chain C21-C40 fragment of azaspiracid-1

Masato Oikawa, Taizo Iwayama, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

Abstract

Here, we report a synthesis of a differentially protected, open-chain C21-C40 fragment of azaspiracid-1, corresponding to the lower half EFGHI-ring domain. The synthesis features modular coupling of three advanced intermediates, aiming for diverted analogue synthesis. A new method for construction of E-ring moiety amenable to the diverted synthesis is also reported.

Original languageEnglish
Pages (from-to)609-615
Number of pages7
JournalHeterocycles
Volume78
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1

Keywords

  • Azaspiracid
  • C21-C40 Fragment
  • Differential Protection
  • EFGHI Ring
  • α-Chlorosulfide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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