Synthesis of octacalcium phosphate with incorporated succinate and suberate ions

Taishi Yokoi, Hidetaka Kato, Ill Yong Kim, Koichi Kikuta, Masakazu Kawashita, Chikara Ohtsuki

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Octacalcium phosphate (OCP) has a layered structure composed of apatitic and hydrated layers. HPO 4 2- in the hydrated layer can be substituted by dicarboxylate ions. The synthesis of octacalcium phosphate with incorporated dicarboxylate ions (octacalcium phosphate carboxylate, OCPC), was investigated through the effects of the initial concentration of dicarboxylic acid on the formation of OCPC. Succinic acid (Suc) and suberic acid (Sub) were used as dicarboxylic acids for preparing OCPC, and crystalline phases of the products were characterized by powder X-ray diffraction (XRD). When the amount of added dicarboxylic acid was 1-5 times the amount corresponding to the stoichiometric composition of OCPC, incorporation of dicarboxylate ions progressed with increasing amount of added dicarboxylic acids, although OCP without incorporated dicarboxylate ions was also present. When the amounts of added Suc and Sub were larger than 10 times the stoichiometric amount in OCPC, a single OCPC phase was detected in the powder XRD patterns. Amounts of Suc and Sub greater than 10 times the stoichiometric amounts facilitated formation of the OCPCs and inhibited formation of OCP. The incorporation of dicarboxylate ions into OCP competes with incorporation of HPO 4 2-. Hence a high concentration of dicarboxylic acids is required for complete incorporation of dicarboxylate ions in OCP.

Original languageEnglish
Pages (from-to)3815-3820
Number of pages6
JournalCeramics International
Issue number5
Publication statusPublished - 2012 Jul


  • A. Powders: chemical preparation
  • B. Nanocomposites
  • E. Biomedical applications
  • Octacalcium phosphate

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Process Chemistry and Technology
  • Surfaces, Coatings and Films
  • Materials Chemistry


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