TY - JOUR
T1 - Synthesis of octacalcium phosphate with incorporated succinate and suberate ions
AU - Yokoi, Taishi
AU - Kato, Hidetaka
AU - Kim, Ill Yong
AU - Kikuta, Koichi
AU - Kawashita, Masakazu
AU - Ohtsuki, Chikara
N1 - Funding Information:
This work was partially supported by a Grant-in-Aid for JSPS Fellows (23·2593) and a Grant-in-Aid for Scientific Research (No. 22107007) on the Innovative Areas of “Fusion Materials: Creative Development of Materials and Exploration of Their Function through Molecular Control” (no. 2206 ) from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) .
PY - 2012/7
Y1 - 2012/7
N2 - Octacalcium phosphate (OCP) has a layered structure composed of apatitic and hydrated layers. HPO 4 2- in the hydrated layer can be substituted by dicarboxylate ions. The synthesis of octacalcium phosphate with incorporated dicarboxylate ions (octacalcium phosphate carboxylate, OCPC), was investigated through the effects of the initial concentration of dicarboxylic acid on the formation of OCPC. Succinic acid (Suc) and suberic acid (Sub) were used as dicarboxylic acids for preparing OCPC, and crystalline phases of the products were characterized by powder X-ray diffraction (XRD). When the amount of added dicarboxylic acid was 1-5 times the amount corresponding to the stoichiometric composition of OCPC, incorporation of dicarboxylate ions progressed with increasing amount of added dicarboxylic acids, although OCP without incorporated dicarboxylate ions was also present. When the amounts of added Suc and Sub were larger than 10 times the stoichiometric amount in OCPC, a single OCPC phase was detected in the powder XRD patterns. Amounts of Suc and Sub greater than 10 times the stoichiometric amounts facilitated formation of the OCPCs and inhibited formation of OCP. The incorporation of dicarboxylate ions into OCP competes with incorporation of HPO 4 2-. Hence a high concentration of dicarboxylic acids is required for complete incorporation of dicarboxylate ions in OCP.
AB - Octacalcium phosphate (OCP) has a layered structure composed of apatitic and hydrated layers. HPO 4 2- in the hydrated layer can be substituted by dicarboxylate ions. The synthesis of octacalcium phosphate with incorporated dicarboxylate ions (octacalcium phosphate carboxylate, OCPC), was investigated through the effects of the initial concentration of dicarboxylic acid on the formation of OCPC. Succinic acid (Suc) and suberic acid (Sub) were used as dicarboxylic acids for preparing OCPC, and crystalline phases of the products were characterized by powder X-ray diffraction (XRD). When the amount of added dicarboxylic acid was 1-5 times the amount corresponding to the stoichiometric composition of OCPC, incorporation of dicarboxylate ions progressed with increasing amount of added dicarboxylic acids, although OCP without incorporated dicarboxylate ions was also present. When the amounts of added Suc and Sub were larger than 10 times the stoichiometric amount in OCPC, a single OCPC phase was detected in the powder XRD patterns. Amounts of Suc and Sub greater than 10 times the stoichiometric amounts facilitated formation of the OCPCs and inhibited formation of OCP. The incorporation of dicarboxylate ions into OCP competes with incorporation of HPO 4 2-. Hence a high concentration of dicarboxylic acids is required for complete incorporation of dicarboxylate ions in OCP.
KW - A. Powders: chemical preparation
KW - B. Nanocomposites
KW - E. Biomedical applications
KW - Octacalcium phosphate
UR - http://www.scopus.com/inward/record.url?scp=84859777880&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859777880&partnerID=8YFLogxK
U2 - 10.1016/j.ceramint.2012.01.030
DO - 10.1016/j.ceramint.2012.01.030
M3 - Article
AN - SCOPUS:84859777880
VL - 38
SP - 3815
EP - 3820
JO - Ceramics International
JF - Ceramics International
SN - 0272-8842
IS - 5
ER -