Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Kimito Kimura, Yoshihisa Hirota, Shigefumi Kuwahara, Atsuko Takeuchi, Chisato Tode, Akimori Wada, Naomi Osakabe, Yoshitomo Suhara

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    We synthesized novel vitamin K2 analogues that incorporated a heteroatom and an aromatic ring in the side chain and evaluated their effect on the selective differentiation of neuronal progenitor cells into neurons in vitro. The results showed that a menaquinone-2 analogue bearing a p-fluoroaniline had the most potent activity, which was more than twice as great as the control. In addition, the neuronal selectivity was more than 3 times greater than the control.

    Original languageEnglish
    Pages (from-to)2591-2596
    Number of pages6
    JournalJournal of Medicinal Chemistry
    Volume60
    Issue number6
    DOIs
    Publication statusPublished - 2017 Mar 23

    ASJC Scopus subject areas

    • Molecular Medicine
    • Drug Discovery

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