Synthesis of Novel Antitumor Agent 1-Methoxy-5,10- dioxo-5,10-dihydro-1H-benzo[g]isochromene Carboxylic Acid (3-Dimethylylaminopropyl)amide with a Dual Role Pd(II) Catalyst

Somnath Mondal, Tsutomu Nogami, Naoki Asao, Yoshinori Yamamoto

    Research output: Contribution to journalArticle

    80 Citations (Scopus)

    Abstract

    A convenient and simple method for the synthesis of 1-methoxy-5,10-dioxo-5,10-dihydro-1H-benzo[g]isochromene-3-carboxylic acid (3-(dimethylamino)propyl)amide 4c was developed. The key step involves the easy formation of 1,3-disubstituted cyclic alkenyl ether, an important framework of isochromene natural products, with a dual role Pd(II) catalyst.

    Original languageEnglish
    Pages (from-to)9496-9498
    Number of pages3
    JournalJournal of Organic Chemistry
    Volume68
    Issue number24
    DOIs
    Publication statusPublished - 2003 Nov 28

    ASJC Scopus subject areas

    • Organic Chemistry

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