Abstract
Two antifungal phthalides produced by a wheat rhizosphere fungus have been synthesized using the Alder-Rickert reaction to construct their common isobenzofuranone core structure. The absolute configuration of one of the two phthalides has been determined to be S by synthesizing its (S)- and (R)-enantiomer and comparing their optical rotations with that of the natural product.
Original language | English |
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Pages (from-to) | 9073-9077 |
Number of pages | 5 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 38 |
DOIs | |
Publication status | Published - 2008 Sep 15 |
Keywords
- Alder-Rickert reaction
- Phthalide
- Take-all
- Total synthesis
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry