Synthesis of novel antifungal phthalides produced by a wheat rhizosphere fungus

Naoto Katoh, Takashi Nakahata, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Two antifungal phthalides produced by a wheat rhizosphere fungus have been synthesized using the Alder-Rickert reaction to construct their common isobenzofuranone core structure. The absolute configuration of one of the two phthalides has been determined to be S by synthesizing its (S)- and (R)-enantiomer and comparing their optical rotations with that of the natural product.

Original languageEnglish
Pages (from-to)9073-9077
Number of pages5
JournalTetrahedron
Volume64
Issue number38
DOIs
Publication statusPublished - 2008 Sep 15

Keywords

  • Alder-Rickert reaction
  • Phthalide
  • Take-all
  • Total synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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