Synthesis of novel antifungal phthalides produced by a wheat rhizosphere fungus

Naoto Katoh, Takashi Nakahata, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Two antifungal phthalides produced by a wheat rhizosphere fungus have been synthesized using the Alder-Rickert reaction to construct their common isobenzofuranone core structure. The absolute configuration of one of the two phthalides has been determined to be S by synthesizing its (S)- and (R)-enantiomer and comparing their optical rotations with that of the natural product.

    Original languageEnglish
    Pages (from-to)9073-9077
    Number of pages5
    JournalTetrahedron
    Volume64
    Issue number38
    DOIs
    Publication statusPublished - 2008 Sep 15

    Keywords

    • Alder-Rickert reaction
    • Phthalide
    • Take-all
    • Total synthesis

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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