TY - JOUR
T1 - Synthesis of novel 1,4-, 3,4-, and 4,5-dihydropyrimidines
T2 - First successful POCl3 chlorination and regioselective alkoxycarbonylation
AU - Cho, Hidetsura
AU - Ohnaka, Yoshiko
AU - Hayashimatsu, Mariko
AU - Ueda, Masaru
AU - Shima, Keiyuu
PY - 1986
Y1 - 1986
N2 - Chlorination of 5,6-dihydropyrimidine-4-(3H)-one derivatives (1) with POCl3 gave 1,4(3,4)-dihydropyrimidines (3), whose alkoxycarbonylation (ClCOOREt3N or NaH) afforded regioselectively novel compounds (4). A new Pummerer type rearrangement of compound (1, XpS(O)CH3) with POCl3, gave compound (5h).
AB - Chlorination of 5,6-dihydropyrimidine-4-(3H)-one derivatives (1) with POCl3 gave 1,4(3,4)-dihydropyrimidines (3), whose alkoxycarbonylation (ClCOOREt3N or NaH) afforded regioselectively novel compounds (4). A new Pummerer type rearrangement of compound (1, XpS(O)CH3) with POCl3, gave compound (5h).
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U2 - 10.1016/S0040-4039(00)87813-2
DO - 10.1016/S0040-4039(00)87813-2
M3 - Article
AN - SCOPUS:0000355354
VL - 27
SP - 6377
EP - 6380
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 52
ER -