Synthesis of monoglucosylated high-mannose-type dodecasaccharide, a putative ligand for molecular chaperone, calnexin, and calreticurin

Ichiro Matsuo, Megumi Wada, Shino Manabe, Yoshiki Yamaguchi, Keisuke Otake, Koichi Kato, Yukishige Ito

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.

Original languageEnglish
Pages (from-to)3402-3403
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number12
DOIs
Publication statusPublished - 2003 Mar 26
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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