Synthesis of Macrotetrolide α, a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

Tadaatsu Hanadate, Hiromasa Kiyota, Takayuki Oritani

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.

    Original languageEnglish
    Pages (from-to)2118-2120
    Number of pages3
    JournalBioscience, Biotechnology and Biochemistry
    Volume65
    Issue number9
    DOIs
    Publication statusPublished - 2001 Sep

    Keywords

    • Bishomononactate
    • Macrotetrolide
    • Optical resolution
    • Polynactin
    • Total synthesis

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Synthesis of Macrotetrolide α, a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids'. Together they form a unique fingerprint.

    Cite this