Synthesis of Macrotetrolide α, a Designed Polynactin Analog Composed of (+)- and (-)-Bishomononactic Acids

Tadaatsu Hanadate, Hiromasa Kiyota, Takayuki Oritani

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Macrotetrolide α, a designed analog of polynactin composed of (+)- and (-)-bishomononactic acids, was synthesized. These monomers were prepared via optical resolution of the corresponding (S)-O-acetylmandelates. Assembly of the monomers to macrotetrolide a look seven steps without any loss of the intermediates.

Original languageEnglish
Pages (from-to)2118-2120
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume65
Issue number9
DOIs
Publication statusPublished - 2001 Sep 1

Keywords

  • Bishomononactate
  • Macrotetrolide
  • Optical resolution
  • Polynactin
  • Total synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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