Synthesis of lysergic acid methyl ester via the double cyclization strategy

Toshiki Kurokawa, Minetaka Isomura, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

An asymmetric synthesis of (+)-lysergic acid methyl ester was accomplished through construction of the tetracyclic ergoline skeleton by double cyclization consisting of intramolecular aromatic amination and Heck reaction.

Original languageEnglish
Pages (from-to)775-778
Number of pages4
JournalSynlett
Issue number5
DOIs
Publication statusPublished - 2009 Mar

Keywords

  • Alkaloids
  • Allylations
  • Aminations
  • Heck reaction
  • Tandem reaction

ASJC Scopus subject areas

  • Organic Chemistry

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