Synthesis of (±)-lecanindole D

Akiko Asanuma, Masaru Enomoto, Tomohiro Nagasawa, Shigefumi Kuwahara

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The first synthesis of the racemate of lecanindole D, an indole sesquiterpenoid with potent and selective agonist activity toward the progesterone receptor, has been achieved from a known tetracyclic alcohol by using a diastereoselective installation of its tertiary hydroxy group via an epoxide intermediate and a Pd(II)-mediated construction of the indole ring moiety as the key transformations.

Original languageEnglish
Pages (from-to)4561-4563
Number of pages3
JournalTetrahedron Letters
Issue number34
Publication statusPublished - 2013 Aug 21


  • Alkaloid
  • Indole sesquiterpene
  • Lecanindole
  • Progesterone receptor agonist

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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