Abstract
Synthesis of dysiherbaine analogue 4, which corresponds to 8,9-epi-neodysiherbaine A, is described. The synthesis features a concise route to the bicyclic ether skeleton through stereoselective C-glycosylation to set the C6 stereocenter and 5-exo ring-closure to form the tetrahydrofuran ring. The results of preliminary biological studies of 4 are also provided.
Original language | English |
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Pages (from-to) | 5559-5562 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 46 |
Issue number | 33 |
DOIs | |
Publication status | Published - 2005 Aug 15 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry