Synthesis of dysiherbaine analogue

Muneo Shoji, Kaoru Shiohara, Masato Oikawa, Ryuichi Sakai, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Synthesis of dysiherbaine analogue 4, which corresponds to 8,9-epi-neodysiherbaine A, is described. The synthesis features a concise route to the bicyclic ether skeleton through stereoselective C-glycosylation to set the C6 stereocenter and 5-exo ring-closure to form the tetrahydrofuran ring. The results of preliminary biological studies of 4 are also provided.

Original languageEnglish
Pages (from-to)5559-5562
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number33
DOIs
Publication statusPublished - 2005 Aug 15

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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