TY - JOUR
T1 - Synthesis of double mesoporous core-shell silica spheres with tunable core porosity and their drug release and cancer cell apoptosis properties
AU - Mohamed El-Toni, Ahmed
AU - Khan, Aslam
AU - Abbas Ibrahim, Mohamed
AU - Puzon Labis, Joselito
AU - badr, Gamal
AU - Al-Hoshan, Mansour
AU - Yin, Shu
AU - Sato, Tsugio
N1 - Funding Information:
The author greatly acknowledges financial support from the NPST program by King Saud University Project Number 10-NAN1035-02 . The author is thankful for Prof. Dongyuan Zhao, Department of Chemistry, Fudan University for his discussions and valuable comments during the preparation of this manuscript.
PY - 2012/7/15
Y1 - 2012/7/15
N2 - In this work, we demonstrate a simple two-pot approach to double mesoporous core-shell silica spheres (DMCSSs) with uniform size of 245-790nm, shell thickness of 41-80nm and surface area and total pore volume of 141-618m 2g -1 and 0.14-0.585ccg -1, respectively. First, solid silica spherical particles were synthesized by the Stöber method and used as a core. Second, a mesoporous shell could be formed around the silica cores by using an anionic surfactant and a co-structure directing agent. It was found that mesopores can be anchored within dense silica cores during mesoporous silica shell formation, synchronously the base group with surfactant assistant can etch the dense silica cores to re-organize new mesostructure, so that double mesoporous core-shell silica sphere (DMCSS) structure can be obtained by a single surfactant-templating step. The spherical size and porosity of the silica cores of DMCSS together with shell thickness can be tuned by controlling Stöber parameters, including the concentrations of ammonia, solvent and tetraethoxysilane and the reaction time. DMCSS were loaded with ketoprofen and thymoquinone, which are an anti-inflammatory and a potential novel anti-cancer drug, respectively. Both drugs showed controlled release behavior from the pores of DMCSS. Drug uptakes within DMCSS were ∼27 and 81wt.% for ketoprofen and thymoquinone, respectively. Furthermore, DMCSS loaded with thymoquinone was more effective in inducing cancer cell apoptosis than uncontained thymoquinone, because of the slow release of the drug from the mesoporous structure.
AB - In this work, we demonstrate a simple two-pot approach to double mesoporous core-shell silica spheres (DMCSSs) with uniform size of 245-790nm, shell thickness of 41-80nm and surface area and total pore volume of 141-618m 2g -1 and 0.14-0.585ccg -1, respectively. First, solid silica spherical particles were synthesized by the Stöber method and used as a core. Second, a mesoporous shell could be formed around the silica cores by using an anionic surfactant and a co-structure directing agent. It was found that mesopores can be anchored within dense silica cores during mesoporous silica shell formation, synchronously the base group with surfactant assistant can etch the dense silica cores to re-organize new mesostructure, so that double mesoporous core-shell silica sphere (DMCSS) structure can be obtained by a single surfactant-templating step. The spherical size and porosity of the silica cores of DMCSS together with shell thickness can be tuned by controlling Stöber parameters, including the concentrations of ammonia, solvent and tetraethoxysilane and the reaction time. DMCSS were loaded with ketoprofen and thymoquinone, which are an anti-inflammatory and a potential novel anti-cancer drug, respectively. Both drugs showed controlled release behavior from the pores of DMCSS. Drug uptakes within DMCSS were ∼27 and 81wt.% for ketoprofen and thymoquinone, respectively. Furthermore, DMCSS loaded with thymoquinone was more effective in inducing cancer cell apoptosis than uncontained thymoquinone, because of the slow release of the drug from the mesoporous structure.
KW - Cancer cell apoptosis
KW - Core-shell
KW - Drug control release
KW - Mesoporous materials
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U2 - 10.1016/j.jcis.2012.04.006
DO - 10.1016/j.jcis.2012.04.006
M3 - Article
C2 - 22551476
AN - SCOPUS:84861572408
VL - 378
SP - 83
EP - 92
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
IS - 1
ER -