Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Haruhiko Fuwa, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.

    Original languageEnglish
    Pages (from-to)4184-4189
    Number of pages6
    JournalBioorganic and Medicinal Chemistry Letters
    Volume16
    Issue number16
    DOIs
    Publication statusPublished - 2006 Aug 15

    Keywords

    • Arylsulfonamides
    • Photoaffinity probes
    • Structure-activity relationships
    • γ-Secretase inhibitors

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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