Synthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors

Haruhiko Fuwa, Kenichi Hiromoto, Yasuko Takahashi, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Synthesis and biological evaluation of an arylsulfonamide class of γ-secretase inhibitors are described. Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported.

Original languageEnglish
Pages (from-to)4184-4189
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number16
DOIs
Publication statusPublished - 2006 Aug 15
Externally publishedYes

Keywords

  • Arylsulfonamides
  • Photoaffinity probes
  • Structure-activity relationships
  • γ-Secretase inhibitors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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