Synthesis of biodegradable hybrid consisting of hydroxyapatite and alginate

C. Ohtsuki; K. Hosoya; T. Kawai; M. Kamitakahara; S. Ogata; T. Miyazaki; M. Tanihara

doi:10.4028/0-87849-961-x.779

Synthesis of biodegradable hybrid consisting of hydroxyapatite and alginate

C. Ohtsuki, K. Hosoya, T. Kawai, M. Kamitakahara, S. Ogata, T. Miyazaki, M. Tanihara

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Hybrids consisting of hydroxyapatite and biodegradable polymers are attractive materials for bone repair. We recently developed hydroxyapatite- alginate hybrids through a soaking process of alginate modified with 3-aminopropyltriethoxysilane (APES), ethylenediamine (EDA) and CaCl₂ in a solution mimicking body fluid such as SBF, 1.5SBF proposed by Kokubo et al. In this study, biological behavior of the apatite-alginate hybrid fabricated through modification with APES and CaCl₂ were evaluated after implantation in a rat tibia, in comparison with that of alginate gel without hydroxyapatite. The higher degree of calcification was observed for the hydroxyapatite-alginate hybrid than the alginate gel without hydroxyapatite. The hydroxyapatite precipitated on and inside alginate allowed the hybrid to show not only osteoconduction but also suitable biodegradation after implantation in bony defect.

Original language	English
Pages (from-to)	779-782
Number of pages	4
Journal	Key Engineering Materials
Volume	284-286
DOIs	https://doi.org/10.4028/0-87849-961-x.779
Publication status	Published - 2005 Jan 1
Externally published	Yes

Keywords

Alginate
Biodegradable material
Hydroxyapatite
Simulated body fluid SBF

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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abstract = "Hybrids consisting of hydroxyapatite and biodegradable polymers are attractive materials for bone repair. We recently developed hydroxyapatite- alginate hybrids through a soaking process of alginate modified with 3-aminopropyltriethoxysilane (APES), ethylenediamine (EDA) and CaCl2 in a solution mimicking body fluid such as SBF, 1.5SBF proposed by Kokubo et al. In this study, biological behavior of the apatite-alginate hybrid fabricated through modification with APES and CaCl2 were evaluated after implantation in a rat tibia, in comparison with that of alginate gel without hydroxyapatite. The higher degree of calcification was observed for the hydroxyapatite-alginate hybrid than the alginate gel without hydroxyapatite. The hydroxyapatite precipitated on and inside alginate allowed the hybrid to show not only osteoconduction but also suitable biodegradation after implantation in bony defect.",

keywords = "Alginate, Biodegradable material, Hydroxyapatite, Simulated body fluid SBF",

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AU - Ohtsuki, C.

AU - Hosoya, K.

AU - Kawai, T.

AU - Kamitakahara, M.

AU - Ogata, S.

AU - Miyazaki, T.

AU - Tanihara, M.

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AB - Hybrids consisting of hydroxyapatite and biodegradable polymers are attractive materials for bone repair. We recently developed hydroxyapatite- alginate hybrids through a soaking process of alginate modified with 3-aminopropyltriethoxysilane (APES), ethylenediamine (EDA) and CaCl2 in a solution mimicking body fluid such as SBF, 1.5SBF proposed by Kokubo et al. In this study, biological behavior of the apatite-alginate hybrid fabricated through modification with APES and CaCl2 were evaluated after implantation in a rat tibia, in comparison with that of alginate gel without hydroxyapatite. The higher degree of calcification was observed for the hydroxyapatite-alginate hybrid than the alginate gel without hydroxyapatite. The hydroxyapatite precipitated on and inside alginate allowed the hybrid to show not only osteoconduction but also suitable biodegradation after implantation in bony defect.

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