Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Hiroshi Tanaka; Yoshikazu Tanaka; Masafumi Minoshima; Sho Yamaguchi; Shinichiro Fuse; Takayuki Doi; Susumu Kawauchi; Hiroshi Sugiyama; Takashi Takahashi

doi:10.1039/c0cc01286f

Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Hiroshi Tanaka, Yoshikazu Tanaka, Masafumi Minoshima, Sho Yamaguchi, Shinichiro Fuse, Takayuki Doi, Susumu Kawauchi, Hiroshi Sugiyama, Takashi Takahashi

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.

Original language	English
Pages (from-to)	5942-5944
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	32
DOIs	https://doi.org/10.1039/c0cc01286f
Publication status	Published - 2010 Aug 28
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c0cc01286f

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Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity. / Tanaka, Hiroshi; Tanaka, Yoshikazu; Minoshima, Masafumi; Yamaguchi, Sho; Fuse, Shinichiro; Doi, Takayuki; Kawauchi, Susumu; Sugiyama, Hiroshi; Takahashi, Takashi.

In: Chemical Communications, Vol. 46, No. 32, 28.08.2010, p. 5942-5944.

Research output: Contribution to journal › Article › peer-review

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AU - Tanaka, Hiroshi

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AU - Minoshima, Masafumi

AU - Yamaguchi, Sho

AU - Fuse, Shinichiro

AU - Doi, Takayuki

AU - Kawauchi, Susumu

AU - Sugiyama, Hiroshi

AU - Takahashi, Takashi

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Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Abstract

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