Abstract
The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.
| Original language | English |
|---|---|
| Pages (from-to) | 5942-5944 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 46 |
| Issue number | 32 |
| DOIs | |
| Publication status | Published - 2010 Aug 28 |
| Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Cite this
Tanaka, H., Tanaka, Y., Minoshima, M., Yamaguchi, S., Fuse, S., Doi, T., Kawauchi, S., Sugiyama, H., & Takahashi, T. (2010). Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity. Chemical Communications, 46(32), 5942-5944. https://doi.org/10.1039/c0cc01286f