Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium

Kou Hiroya; Taisuke Takahashi; Nobuhiko Miura; Akira Naganuma; Takao Sakamoto

doi:10.1016/S0968-0896(02)00172-4

Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium

Kou Hiroya, Taisuke Takahashi, Nobuhiko Miura, Akira Naganuma, Takao Sakamoto

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

The protecting effect of betulin against cadmium toxicity was investigated using 11 inds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.

Original language	English
Pages (from-to)	3229-3236
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	10
Issue number	10
DOIs	https://doi.org/10.1016/S0968-0896(02)00172-4
Publication status	Published - 2002

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0968-0896(02)00172-4

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abstract = "The protecting effect of betulin against cadmium toxicity was investigated using 11 inds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.",

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AU - Hiroya, Kou

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AU - Miura, Nobuhiko

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AU - Sakamoto, Takao

PY - 2002

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AB - The protecting effect of betulin against cadmium toxicity was investigated using 11 inds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.

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ER -

Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium

Abstract

ASJC Scopus subject areas

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