Synthesis of betulin derivatives and their protective effects against the cytotoxicity of cadmium

Kou Hiroya, Taisuke Takahashi, Nobuhiko Miura, Akira Naganuma, Takao Sakamoto

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The protecting effect of betulin against cadmium toxicity was investigated using 11 inds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.

Original languageEnglish
Pages (from-to)3229-3236
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number10
DOIs
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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