Abstract
The protecting effect of betulin against cadmium toxicity was investigated using 11 inds of analogues. It was elucidated by analyzing the analogue activities that both hydroxyl groups on C-3 and C-28 and the isopropenyl group on C-19 played important roles for expressing efficient activities. In addition, the cytotoxicity of betulin was also reduced by being functionalized using the above functional group.
Original language | English |
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Pages (from-to) | 3229-3236 |
Number of pages | 8 |
Journal | Bioorganic and Medicinal Chemistry |
Volume | 10 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2002 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry