Synthesis of aurachins B and H

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    1 Citation (Scopus)


    The synthesis of aurachin B, an antibiotic that features a C3-oxygen-substituted quinoline N-oxide nucleus bearing a farnesyl side chain at C4, was accomplished in 60% overall yield from o-nitro-toluene by a concise five-step sequence. An enantioselective synthesis of aurachin H was also achieved for the first time in only two steps from an optically active epoxy iodide.

    Original languageEnglish
    Pages (from-to)1466-1469
    Number of pages4
    JournalBioscience, Biotechnology and Biochemistry
    Issue number8
    Publication statusPublished - 2017


    • Aurachin B
    • Aurachin H
    • Quinoline N-oxide
    • Quinoline antibiotics
    • Reductive cyclization

    ASJC Scopus subject areas

    • Biotechnology
    • Analytical Chemistry
    • Biochemistry
    • Applied Microbiology and Biotechnology
    • Molecular Biology
    • Organic Chemistry


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