TY - JOUR
T1 - Synthesis of an enantiomeric DNA oligomer and its T-HgII-T base-pair formation.
AU - Haruta, Kaichiro
AU - Tanaka, Yoshiyuki
AU - Kawamura, Takuya
AU - Kondo, Yoshinori
AU - Ono, Akira
AU - Yamakoshi, Hiroyuki
AU - Kanoh, Naoki
AU - Iwabuchi, Yoshiharu
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2007
Y1 - 2007
N2 - Unnatural "L-DNA" containing 2'-deoxy-L-ribose backbone instead of natural 2'-deoxy-D-ribose was synthesized and evaluated by (1)H NMR, CD spectra. Proton ((1)H) NMR spectra of natural DNA (D-TpT) and L-DNA (L-TpT) are fully consistent with each other. In CD spectra, however, spectrum of L-TpT was reversed, relative to that of D-TpT. These results indicate that L-TpT is an isomer with a mirror image configuration of D-TpT. In summary, we have synthesized enantiomeric L-DNA, and the L-DNA would be materials for nanodevices and tools for exploring why the D-isomer of DNA molecules was selected as a bio-molecule.
AB - Unnatural "L-DNA" containing 2'-deoxy-L-ribose backbone instead of natural 2'-deoxy-D-ribose was synthesized and evaluated by (1)H NMR, CD spectra. Proton ((1)H) NMR spectra of natural DNA (D-TpT) and L-DNA (L-TpT) are fully consistent with each other. In CD spectra, however, spectrum of L-TpT was reversed, relative to that of D-TpT. These results indicate that L-TpT is an isomer with a mirror image configuration of D-TpT. In summary, we have synthesized enantiomeric L-DNA, and the L-DNA would be materials for nanodevices and tools for exploring why the D-isomer of DNA molecules was selected as a bio-molecule.
UR - http://www.scopus.com/inward/record.url?scp=42949160665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=42949160665&partnerID=8YFLogxK
U2 - 10.1093/nass/nrm094
DO - 10.1093/nass/nrm094
M3 - Article
C2 - 18029649
AN - SCOPUS:42949160665
SP - 187
EP - 188
JO - Nucleic acids symposium series (2004)
JF - Nucleic acids symposium series (2004)
SN - 1746-8272
IS - 51
ER -