Abstract
4P-X (β-D-galactopyranosyl-(1 → 4)-β-D-galactopyranosyl-(1 → 6)-[β-D-galactopyranosyl-(1 → 4)]-β-D-glucopyranose) is included in galacto-oligosaccharides (GOSs) produced by β-galactosidase derived from Bacillus circulans. 4P-X has been known to induce particularly strong allergies. High purity 4P-X is essential for use as a standard to quantify the amount of 4P-X in GOSs; however, the isolation of high purity 4P-X has never been reported. In this study, we achieved the synthesis of 4P-X by a combination of organic and enzymatic chemical syntheses in a short time. This is the first report of isolated, high purity 4P-X.
| Original language | English |
|---|---|
| Pages (from-to) | 44-49 |
| Number of pages | 6 |
| Journal | Carbohydrate Research |
| Volume | 439 |
| DOIs | |
| Publication status | Published - 2017 Jan 1 |
Keywords
- 4P-X
- Allergy
- Galacto-oligosaccharides
- Oligosaccharide synthesis
ASJC Scopus subject areas
- Analytical Chemistry
- Biochemistry
- Organic Chemistry
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Cite this
Moriya, T., Nagahata, N., Odaka, R., Nakamura, H., Yoshikawa, J., Kurashima, K., & Saito, T. (2017). Synthesis of an allergy inducing tetrasaccharide “4P-X”. Carbohydrate Research, 439, 44-49. https://doi.org/10.1016/j.carres.2016.11.013