Synthesis of an allergy inducing tetrasaccharide “4P-X”

Takashi Moriya, Naoki Nagahata, Rei Odaka, Hirohide Nakamura, Jun Yoshikawa, Katsumi Kurashima, Tadao Saito

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

4P-X (β-D-galactopyranosyl-(1 → 4)-β-D-galactopyranosyl-(1 → 6)-[β-D-galactopyranosyl-(1 → 4)]-β-D-glucopyranose) is included in galacto-oligosaccharides (GOSs) produced by β-galactosidase derived from Bacillus circulans. 4P-X has been known to induce particularly strong allergies. High purity 4P-X is essential for use as a standard to quantify the amount of 4P-X in GOSs; however, the isolation of high purity 4P-X has never been reported. In this study, we achieved the synthesis of 4P-X by a combination of organic and enzymatic chemical syntheses in a short time. This is the first report of isolated, high purity 4P-X.

Original languageEnglish
Pages (from-to)44-49
Number of pages6
JournalCarbohydrate Research
Volume439
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • 4P-X
  • Allergy
  • Galacto-oligosaccharides
  • Oligosaccharide synthesis

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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  • Cite this

    Moriya, T., Nagahata, N., Odaka, R., Nakamura, H., Yoshikawa, J., Kurashima, K., & Saito, T. (2017). Synthesis of an allergy inducing tetrasaccharide “4P-X”. Carbohydrate Research, 439, 44-49. https://doi.org/10.1016/j.carres.2016.11.013