Synthesis of acyclic α,β-unsaturated ketones via Pd(II)-catalyzed intermolecular reaction of alkynamides and alkenes

Norie Momiyama, Matthew W. Kanan, David R. Liu

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

We report an intermolecular oxidative coupling of alkynamides and terminal alkenes to synthesize E-α,β-unsaturated ketones under very mild conditions using catalytic Pd(II) and an oxidant. An 17O isotope labeling experiment implicates a cyclic oxypalladation intermediate in this reaction.

Original languageEnglish
Pages (from-to)2230-2231
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number8
DOIs
Publication statusPublished - 2007 Feb 28

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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