Synthesis of actiketal, a glutarimide antibiotic

Hiromasa Kiyota, Yuko Shimizu, Takayuki Oritani

    Research output: Contribution to journalArticlepeer-review

    22 Citations (Scopus)

    Abstract

    The first synthesis of actiketal (RK-441S), an antibiotic from Streptomyces pulveraceus subsp. epiderstagenes, was achieved from 5,7- dimethylbenzofuran and dimethyl glutaconate via palladium-assisted coupling reaction as a key step. (C) 2000 Elsevier Science Ltd.

    Original languageEnglish
    Pages (from-to)5887-5890
    Number of pages4
    JournalTetrahedron Letters
    Volume41
    Issue number31
    DOIs
    Publication statusPublished - 2000 Jul 29

    Keywords

    • Acetals
    • Antibiotics
    • Glutarimides
    • Polyketides

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry

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