Synthesis of a novel bioactive photoaffinity probe based on a leaf-movement factor with potential high binding affinity to its receptor molecule

Tomohiko Fujii, Takanori Sugimoto, Shosuke Yamamura, Minoru Ueda

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Nyctinastic leaf-movement is induced by the binding of the leaf-movement factor with a motor cell located in the pulvini of the plant. Some receptors of the leaf-movement factor should be involved in this biological event. We developed a novel photoaffinity probe (1) for the detection of receptor molecules. Probe compound 1 bears a photolabeling group on the 2′-position of the glycon moiety, which is near the potential binding site of the molecule with its receptor. This molecular design would be effective for the improvement of photolabeling yield.

Original languageEnglish
Pages (from-to)2497-2499
Number of pages3
JournalTetrahedron Letters
Volume44
Issue number12
DOIs
Publication statusPublished - 2003 Mar 17

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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