Synthesis of a Nine‐Membered Cyclic Analogue of the Neocarzinostatin Chromophore and Its DNA‐Cleaving Activity

Takashi Takahashi, Hiroshi Tanaka, Yoshimasa Hirai, Takayuki Doi, Haruo Yamada, Takashi Shiraki, Yukio Sugiura

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The highly strained but relatively stable analogue 1 of the neocarzinostatin chromophore was synthesized by a transannular [2,3]‐Wittig rearrangement and characterized. Diyne 1 is the first analogue of this type with DNA cleaving activity and may thus have potential as an anticancer agent. (Figure Presented.)

Original languageEnglish
Pages (from-to)1657-1659
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume32
Issue number11
DOIs
Publication statusPublished - 1993 Nov
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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