Synthesis of a bridging ligand with a non-denatured protein pendant: Toward protein encapsulation in a coordination cage

Daishi Fujita, Kosuke Suzuki, Sota Sato, Maho Yagi-Utsumi, Eiji Kurimoto, Yoshiki Yamaguchi, Koichi Kato, Makoto Fujita

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Toward protein encapsulation by a synthetic host, we synthesized an ubiquitin-dangled ligand, a potential precursor of a nanoscale coordination cage. The key step is the addition of a C-terminal Cys76 SH group, which was introduced by Gly76Cys mutation, to a maleimide acceptor on the ligand. The C-terminal mutation and the SH addition to the ligand did not damage the ubiquitin moiety at all, neither structurally nor conformationally.

    Original languageEnglish
    Pages (from-to)313-315
    Number of pages3
    JournalChemistry Letters
    Volume41
    Issue number3
    DOIs
    Publication statusPublished - 2012

    ASJC Scopus subject areas

    • Chemistry(all)

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