Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9h-adenine (a lowe] methylene homolog of carbocyclic oxetanocin) and related compounds

Nobuya Katagiri; Hiroshi Sato; Chikara Kaneko

doi:10.1248/cpb.38.3184

Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9h-adenine (a lowe] methylene homolog of carbocyclic oxetanocin) and related compounds

Nobuya Katagiri, Hiroshi Sato, Chikara Kaneko

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.

Original language	English
Pages (from-to)	3184-3186
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	38
Issue number	11
DOIs	https://doi.org/10.1248/cpb.38.3184
Publication status	Published - 1990

Keywords

BLV
adenine
antiviral activity
carbocyclic oxetanocin
cyclopropane
high pressure
thymine

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.38.3184

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title = "Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9h-adenine (a lowe] methylene homolog of carbocyclic oxetanocin) and related compounds",

abstract = "To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.",

keywords = "BLV, adenine, antiviral activity, carbocyclic oxetanocin, cyclopropane, high pressure, thymine",

author = "Nobuya Katagiri and Hiroshi Sato and Chikara Kaneko",

year = "1990",

doi = "10.1248/cpb.38.3184",

language = "English",

volume = "38",

pages = "3184--3186",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

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T1 - Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9h-adenine (a lowe] methylene homolog of carbocyclic oxetanocin) and related compounds

AU - Katagiri, Nobuya

AU - Sato, Hiroshi

AU - Kaneko, Chikara

PY - 1990

Y1 - 1990

N2 - To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.

AB - To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.

KW - BLV

KW - adenine

KW - antiviral activity

KW - carbocyclic oxetanocin

KW - cyclopropane

KW - high pressure

KW - thymine

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DO - 10.1248/cpb.38.3184

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EP - 3186

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 11

ER -

Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9h-adenine (a lowe] methylene homolog of carbocyclic oxetanocin) and related compounds

Abstract

Keywords

ASJC Scopus subject areas

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