Synthesis of 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9h-adenine (a lowe] methylene homolog of carbocyclic oxetanocin) and related compounds

Nobuya Katagiri, Hiroshi Sato, Chikara Kaneko

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.

Original languageEnglish
Pages (from-to)3184-3186
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number11
DOIs
Publication statusPublished - 1990

Keywords

  • BLV
  • adenine
  • antiviral activity
  • carbocyclic oxetanocin
  • cyclopropane
  • high pressure
  • thymine

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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