Abstract
To clarify the relationship of side chain conformation and flexibility to biological activity, a series of carbocyclic analogs of oxetanocin having a one-methylene unit shorter in the cyclobutane ring, 9-(t-2,c-3-dihydroxymethyl-r-l-cyclopropyl)-9H-adenine (11) and the related compounds (15, 18, and 19) were synthesized.
Original language | English |
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Pages (from-to) | 3184-3186 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 38 |
Issue number | 11 |
DOIs | |
Publication status | Published - 1990 |
Keywords
- BLV
- adenine
- antiviral activity
- carbocyclic oxetanocin
- cyclopropane
- high pressure
- thymine
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery