Synthesis of 9-membered masked enediyne analogues possessing DNA intercalator and sugar moieties

Takashi Takahashi, Hiroshi Tanaka, Akihisa Matsuda, Takayuki Doi, Haruo Yamada

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Syntheses of hybrid DNA cleaving molecules which have the 9-membered enediyne structure of kedarcidin with the DNA intercalator of NCS and/or the sugar moieties were accomplished. Introduction of the sugar moieties to the masked enediyne was achieved via S-alkylation of a bromoacetate derivative with a sugar-containing thiol without the need for protection of the sugar moiety.

Original languageEnglish
Pages (from-to)3299-3302
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number23
DOIs
Publication statusPublished - 1998 Dec 1
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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