Synthesis of 6-amino-2-vinylpurine derivatives for cross-linking and evaluation of the reactivity

Shuhei Kusano, Tomoya Sakuraba, Shinya Hagihara, Fumi Nagatsugi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Oligodeoxynucleotides (ODNs) have been widely used for inhibiting the gene expression in antisense or antigene methods, and the interstrand cross-linking (ICL) forming ODNs have been expected to ensure the inhibition by these methods. Previously, we reported a highly efficient and selective ICL reaction toward cytosine using the 2-amino-6-vinylpurine derivative under acidic conditions. In this Letter, we report the synthesis of ODN containing 6-amino-2-vinylpurine derivatives and evaluation of the cross-linking reactivity.

Original languageEnglish
Pages (from-to)6957-6961
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number22
DOIs
Publication statusPublished - 2012 Nov 15

Keywords

  • Antisense
  • Cross-linking
  • Oligonucleotides
  • Purine derivatives
  • miRNA

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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